Cholinergic system - Tapuz

Cholinergic system - Tapuz

The Cholinergic System Sites of actions of cholinergic agonists Synthesis and release of acetylcholine

:

- (.)M1,M2,M3,M4,M5 , :M1CNS, gastric parietal cells

: M2 , : M3 , CNS :M4 CNS :M5 M1/M3

, Nn .Nm NN 2- . 2 NM- 2 , . 2

. ( -5) , ( . NN) - ( . 2 ).

M2 / signal transduction M1,M3,M5 ( G-protein )Gq PLC

PIP2 DAG, IP3 Ca . . . M2,M4( G-protein )GiAdenylyl cyclase K) : ( * ( K ) hyperpolarization ()SA node * Ca

: " ()NN ()NN ()NN

- (.)NM( )NMJ NMJ- " (-hexamethonium )tubocurarine NN

NM

( , ( ,)NO -M3 )

, , , (,)miosis , ,, , .

" .AChE

: Bethanechol ACh " AChE

. : Carbachol . ( CV

GI , ) . : Pilocarpine

". AChE . ( )intraocular .glaucoma . : ".

Acetylcholinesteras e ,

, " ( . ) , .

esteratic anionic ()AChEI ACh

. :AChE edrophonium - Neostigmine physostigmine -echothiophate -

Neostigmine - ((NCOO ) , ' )

. ()AChEI :Neostigmine

-. GI . 2-4. myasthenia gravis- ,

()AChEI Physostigmine ) : ( ", ,GI- miosis-

) (. pilocarpine : ;Ach . " NMJ- . :Pyridostigmine

3-6 . Myasthenia gravis :Edrophonium , ( 10-20). MG

()AChEI -

- isofluorphate )DFP(, Parathion- : . . .

: . Pralidoxime)-PAM2( : "" , SER-O- P

, , .

Atropine, Scopolamine belladonna Ach

M .Ach Atropine Scopolamine ( ')

Atropine : : :GI :

: , : -ACh ( ,)NN

(.)NM ," , " . .

Nicotine , - (" , ) ,

Trimethaphan - , . " . IV

, .

- Antagonists (nondepolarizing) Agonists (depolarizing)

non-depolarizing agents . tubocurarine, pancoronium, : .gallamine

non-depolarizing agents ACh : , , , , , :

non-depolarizing agents AChE ()halotane

depolarizing agents ACh ,

succinylcholine

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