CHMI 2227E Biochemistry I - cellbiochem.ca

CHMI 2227E Biochemistry I - cellbiochem.ca

CHMI 2227E Biochemistry I Proteins: Secondary Structure - Beta Strands and Beta Sheets - Loops and Turns - A special case: Collagen - CHMI 2227 - E.R. Gauthier, Ph.D.

1 Beta Strands and Beta Sheets CHMI 2227 - E.R. Gauthier, Ph.D. 2 Beta Sheets

CHMI 2227 - E.R. Gauthier, Ph.D. 3 Hydrogen Bonded Beta Strands N C

N C N C N

C CHMI 2227 - E.R. Gauthier, Ph.D. 4 Antiparallel Beta Strands http://dbs.umt.edu/courses/fall2006/bioc380/lectures/011/lecture.html CHMI 2227 - E.R. Gauthier, Ph.D.

5 Parallel Beta Strands http://dbs.umt.edu/courses/fall2006/bioc380/lectures/011/lecture.html CHMI 2227 - E.R. Gauthier, Ph.D. 6

Mixed Beta Sheets CHMI 2227 - E.R. Gauthier, Ph.D. 7 Beta Sheet Conformation http://dbs.umt.edu/courses/fall2006/bioc380/lectures/011/lecture.html

CHMI 2227 - E.R. Gauthier, Ph.D. 8 Beta Pleated Sheets Beta Pleated Sheets: Silk CHMI 2227 - E.R. Gauthier, Ph.D.

9 Loops and Turns CHMI 2227 - E.R. Gauthier, Ph.D. 10 Loops and Turns

CHMI 2227 - E.R. Gauthier, Ph.D. 11 Loops and Turns CHMI 2227 - E.R. Gauthier, Ph.D. 12

Beta turns http://web.chemistry.gatech.edu/~williams/bCourse_Information/6521/ protein/secondary_structure/beta_turn/down/beta_turn_1.jpg CHMI 2227 - E.R. Gauthier, Ph.D. 13 A special case : collagen

Type I bone, tendon, fibrocartilage, dermis, cornea Type II nucleus pulposus, hyaline cartilage Type III

intestinal and uterine wall Type IV endothelial, epithelial membranes Type V* cornea, placenta, bone, heart valve

* Found in small quantities CHMI 2227 - E.R. Gauthier, Ph.D. 14 A special case : collagen Chain 1 Chain 2

Chain 3 Triple helix (from Kadler, 1996) CHMI 2227 - E.R. Gauthier, Ph.D. 15

A special case : collagen Hypro 5-Hylys CHMI 2227 - E.R. Gauthier, Ph.D. 16 A special case : collagen

13 CHMI 2227 - E.R. Gauthier, Ph.D. 17 A special case : collagen CHMI 2227 - E.R. Gauthier, Ph.D.

18 Hydrogen bonds stabilize the collagen triple helix Gly of Chain 1 G Glycine Hypro

Pro Pro of Chain 2 CHMI 2227 - E.R. Gauthier, Ph.D. 19 Formation of collagen fibers Lysine

Collagen triple helix (tropocollagen) Lysine Collagen triple helix (tropocollagen) CHMI 2227 - E.R. Gauthier, Ph.D. 20

Formation of collagen fibers Transmission electron microscopy of collagen fibers CHMI 2227 - E.R. Gauthier, Ph.D. 21

Collagen, Vitamin C and scurvy CHMI 2227 - E.R. Gauthier, Ph.D. 22

Recently Viewed Presentations

  • Sepsis à BGN (bacilles à gram négatif)

    Sepsis à BGN (bacilles à gram négatif)

    Définitions ( Consensus SFAR, SRLF 2003) I C. Les états septiques sont caractérisés par l'hétérogénéité des terrains, des pathogènes responsables, des variations physiopathologiques, des présentations cliniques, du degré d'évolution lors de la prise en charge et des réponses aux thérapeutiques...
  • Political Parties - images.pcmac.org

    Political Parties - images.pcmac.org

    Parties and What They Do. What is a political party? A group of persons who . seek to control govt. thru the winning of elections and holding of public office
  • Electronic Guideposts for Students' Exploration of Career ...

    Electronic Guideposts for Students' Exploration of Career ...

    Created guideposts can be adapted for other CTE programs offered at the College's district high schools. Guideposts are electronic documents that are live and are updated as requirements, syllabi, and offerings change. Guideposts are easily accessed on the College's website...
  • Maine Workers' Compensation Board

    Maine Workers' Compensation Board

    102(12 ) - If the employer is insured, "employer" includes the insurer, self-insurer or group self-insurer unless the. contrary intent is apparent from the context or is inconsistent with the purposes of this Act.
  • CARIN Blue Button Framework

    CARIN Blue Button Framework

    Harmonized. CPCDS Element. MapID. R4 Resource. Profile Element. 24. Claim payee . 121. ExplanationOfBenefit.payee.party. 25. Claim payment status code. 91 ...
  • Bild 1 - miun.se

    Bild 1 - miun.se

    Add or subtract two of these numbers in three-tenths of a second. Multiply them in four seconds. Divide them in ten seconds. Store 72 numbers. "Six electronic digital computers would be sufficient to satisfy the computing needs of the entire...
  • A Escola Austríaca e a Teoria do Valor

    A Escola Austríaca e a Teoria do Valor

    A Escola Austríaca e a Teoria do Valor Prof. Dr. Antony P. Mueller UFS 11 de Maio de 2010 Quem foi Ludwig von Mises? Nasceu 20 de Setembro de 1881 em Lemberg, Império Austro-Húngaro Faleceu 10 de Outubro de 1973...
  • nsidc.org

    nsidc.org

    OPERATIONAL and USER STATISTICS User Metrics Distribution and Ingest Metrics User Statistics Quick View -Throughput Ingest Function ~17 TB/year Archive Function 2-3 TB/month Curre